Kamloops-South Thompson is a former provincial electoral district in British Columbia, Canada in use from 2009 to 2024.

Under the 2021 British Columbia electoral redistribution that effect for the 2024 general election, both this riding and its sibling Kamloops-North Thompson were significantly reorganized, resulting in much of the eastern and rural portions of Kamloops-South Thompson's population being redistributed into Kamloops-North Thompson and the creation of the new district of Kamloops Centre taking in much of its western end.

As of the 2020 provincial election, Kamloops-South Thompson comprised the eastern portion of the Thompson-Nicola Regional District.

Communities in the electoral district consisted of Kamloops, south of the Thompson river and Chase.

[1] On account of the realignment of electoral boundaries, most incumbents did not represent the entirety of their listed district during the preceding legislative term.