Like its real world counterpart, there are many retail shops, izakaya, restaurants, and mizu shōbai establishments like host and hostess clubs, soaplands, and nightclubs within the district.

A constant fixture of Sega's interactive urban planning across the franchise's in-universe continuity, Kamurochō has been cited as a notable example of an effective, flexible cityscape primed for "virtual tourism".

Producer Masayoshi Kikuchi and writer Hiroyuki Sakamoto, the primary author of the first Yakuza's side stories, supervised numerous aspects of the setting, from the district's neon signs and crowded streets to conversations with hostess club female employees.

According to Kikuchi, Kabukichō is within an hour away from Sega's development office, so team members could make frequent short trips to take videos or photos for each game.

Team members, led by Nagoshi, would also visit drinking establishments within the Roppongi and Kabukicho districts at least two or three nights each week and converse with people in the local area as part of their research.

Sega originally faced difficulty securing collaborations with established companies for product placement due to the real-world cultural stigma surrounding yakuza culture as well as the mature nature of the video game series' content, though Suntory emerged as one of the series' early supporters as the game's player demographic is perceived to be compatible with the whiskey-drinking demographic.

[6] Spin-off media which feature Kamurochō as an important setting include the Kurohyō sub-series which follows delinquent youth Tatsuya Ukyo;[7] Yakuza: Dead Souls, which depicts several major characters confronting a zombie-infested Kamurochō; Ryū ga Gotoku Online, a mobile game which feature several story scenarios set within the district; and the Judgment video game sub-series, which stars private detective Takayuki Yagami.

[11] Kamurochō has received acclaim from critics and the wider video game community for its authentic, and at times near-identical, recreation of Kabukichō's culture and sights.

[20][21] Several critics agree that while Kamurochō has remained a familiar constant in the franchise, even with the passage of time, plot developments in each succeeding title irreversibly transform specific localities within the district and ensure that the location is never quite the same from one game to the next.

[12] Alex Bosso from Playstation Lifestyle considered Kamurochō to be a character in its own right due to the immersion and “realistic feeling” it provides, singling out its iteration in Yakuza 0 as a series highlight.

[25] In response to the impending release of Yakuza: Like a Dragon and its apparent break from its predecessors over many of the franchise's conventions and traditions, Tyler Treese from GameRevolution lamented the possible reduction of Kamurochō's importance and prominence within series canon.