US Route 66 was designated in 1926; by 1929 Kansas and Illinois were the first to completely pave their respective segments of this highway.

[3] Little's Service Station installed its fuel pumps on the former site of the Banks Hotel[4] (demolished 1933) at 119 North Main Street in Galena;[5] an automobile repair shop was added later.

US 66 would become Kansas State Route 66 in 1985, but the station sat vacant, closed and largely abandoned until its 2007 restoration.

[8] In April 2011, a Disney/Pixar crew returned[9] to interview the station's owners for a DVD release of Cars 2.

[14] Located seven blocks north of the current (7th Street) Kansas Route 66, the station retains the original aesthetic design of the fuel pumps and exterior façade but places a diner-style lunch counter in what once would have been the service bay of the station's repair garage.