[1] The stream headwaters arise at 37°29′31″N 112°22′50″W / 37.49194°N 112.38056°W / 37.49194; -112.38056[2] at an elevation of approximately 8600 feet along the base of the Sunset Cliffs.
It continues to the south and runs parallel to U.S. Route 89 past Kanab.
[4] The stream enters Arizona where it becomes the border between Coconino and Mohave counties and flows past Fredonia.
It flows through the Kaibab Indian Reservation of the Paiute people and the Kanab Creek Wilderness before reaching its confluence with the Colorado at 36°23′32″N 112°37′48″W / 36.39222°N 112.63000°W / 36.39222; -112.63000 at an elevation of 1913 feet[2] within the Grand Canyon National Park.
[5] The valley of Kanab Creek was settled by Basketmaker and Anasazi Indians.