She has sung a large number of songs that have been used in a variety of video games, visual novels, and anime.

Itō has sung songs for many visual novels, one song in particular being "Kanashimi no Mukō e" (悲しみの向こうへ), the "bad end" ending theme to the visual novel School Days.

Itō has also sung songs for a drama CD and anime adaptations of School Days.

She has sung songs for the games Kikokugai: The Cyber Slayer, Saya no Uta, Demonbane, Higurashi no Naku Koro ni Matsuri, Chaos;Head, Chaos;Child, Steins;Gate, and Robotics;Notes, along with the anime series Please Twins!, Myself; Yourself, Hatenkō Yūgi and Occultic;Nine.

In April 2012, she made her American performance debut at Anime Boston.