After Brown signed with RCA Nashville in early 2016, the song was included on his second EP and major label debut, Chapter 1 in March 2016.

The album spawned the single "What Ifs" (featuring Lauren Alaina), and in October 2017, Brown became the first artist to have simultaneous number ones on all five main Billboard country charts.

[13] Sometimes homeless, Brown's family moved around northwest Georgia when he was younger from Rossville to Fort Oglethorpe to LaFayette before finally settling in Red Bank, Tennessee.

However, after almost winning a school talent show in 11th grade with a rendition of Chris Young's "Gettin' You Home", he began to perform country music.

[19][20] In 2014, Kane Brown began posting videos of his covers of songs by Brantley Gilbert, Billy Currington, Alan Jackson, and other singers on social media.

[11] In 2014, Brown raised funds via crowdfunding site Kickstarter to produce a six-song EP,[23] which he recorded in Nashville, Tennessee, at the home studio of Noah Henson, guitarist for Brantley Gilbert.

[24] A single from the EP, "Don't Go City on Me", was first released on October 22, 2014, and reached number 43 on the Country Digital Songs chart.

[25] Brown released a new single "Used to Love You Sober" on his birthday (October 21) in 2015, and the song was spotlighted on Zane Lowe's Beats 1.

[26] It reached number two on the Country Digital Songs chart based on just two days of sales, with 38,000 copies sold.

[30] Brown opened for Florida Georgia Line on their summer 2016 Dig Your Roots Tour[31] and collaborated with Chandler Stephens on a song they wrote together, "Can't Stop Love", which released on February 12, 2016.

[36][37] "Thunder in the Rain" was released as the debut radio single from the album on August 3, 2016, and Brown headlined his own Ain't No Stopping Us Now Tour produced by Monster Energy and Outbreak Presents starting on November 3, 2016.

On September 4, 2018, Brown announced the album's title, Experiment, via Twitter along with its cover art and news of the upcoming track "Homesick".

[52] In June 2020, Brown released the song "Worldwide Beautiful", which aims to highlight peace and equality and benefits the Boys & Girls Club of America.

[56] That same week Brown appeared on stage at the iHeartRadio Music Festival in a PORTL "hologram" machine to sing "Be Like That" live from Nashville with Swae Lee and Khalid who were in the studio in Los Angeles, California.

[58] On November 26, 2020, Brown performed in a pre-recorded halftime show in the Thanksgiving Thursday Night Football game between the Washington Commanders and the Dallas Cowboys at AT&T Stadium.

[60] Also in 2021, Brown became the first black person to win Video of the Year at the ACM Awards, which he won for "Worldwide Beautiful".

He proposed to her on Easter Sunday in 2017 and announced their engagement during a concert in Philadelphia, Pennsylvania, a short time later in April 2017.