Kapelle-op-den-Bos (Dutch pronunciation: [kaːˈpɛlə ʔɔb dɛm ˈbɔs]) is a municipality located in the Belgian province of Flemish Brabant.

The municipality comprises the towns of Kapelle-op-den-Bos proper, Nieuwenrode and Ramsdonk.

Located at the intersection of the Willebroek to Brussels shipping canal and the Mechelen-Ghent railway line, the town is home to the Etex Group NV group of companies, which manufacture piping, roofing, gyprock and cement products.

The town was a target for heavy bombing during the First World War due to its proximity to transport routes.

Among the many buildings destroyed was the parish church dedicated to Saint Nicholas, which was later rebuilt with a modern flavour; the nave retained its original arched windows, but the steeple now appears as a crown.