In 1871, the line reached Edirne but in order to avoid building a bridge across the Maritsa River, the station was built in Karaağaç in 1873.

Edirne was a former capital in the Ottoman Empire, noted for grand architecture, and in 1914 the larger station was built that stands today, designed by Ahmet Kemaleddin[3][2] in the Turkish Neoclassical style, similar to Sirkeci railway station in Istanbul.

[4] The line was used by the Greek State Railways (OSE) until 1971 when the Turkish State Railways (TCDD) built a line from Pehlivanköy through the city of Edirne to the Bulgarian border, and OSE built a short cut-off between Marasia and Nea Vyssa to avoid Turkish territory near Edirne.

[3] Following redevelopment works, the railway station building was converted into Faculty of Fine Arts of Trakya University in Edirne.

Opened in 1998, the Treaty of Lausanne Monument and Museum are located next to the former railway station.