[19][20] In the revival of the Mirage Studios' series by Peter Laird and Jim Lawson (without Eastman's involvement), Karai has returned to settle in New York and is using a high-tech armor.

[29] A few weeks later, Karai visits a local high-profile nightclub, meeting Casey Jones, still longing for his wife April O'Neil who has gone on a soul-searching pilgrimage.

[38] According to Complex, "since her comic book debut, Karai has become an extremely popular character, serving as the sometimes villain, sometimes uneasy ally of our fearsome foursome.

"[39] A completely different and much younger Karai appears in IDW Publishing's ongoing, re-imagined Teenage Mutant Ninja Turtles reboot series by Kevin Eastman, Tom Waltz and Dan Duncan (later also Andy Kuhn and Mateus Santolouco).

Her backstory is told in Villain Mini-series #5: as a young girl, Karai found the Ashi no Himitsu, a book detailing the secret history of the Foot Clan, in the library of her father, Oroku Yori.

She gets involved in a turf war between two Yakuza clans and is nudged by one of their leaders into embarking on a quest to recover the Kira no Ken, an ancient sword imbued with mystical powers.

Leonardo, believing that her Karai is honorable despite her legacy, convinces Donatello, Michelangelo, and Casey Jones to aid her (Raphael initially refuses).

Karai's internal conflict between her sense of honor and loyalty to her evil father is the main thrust of her storyline in the third season, as she is pulled from both directions to take a side during their various encounters, even working together with the Turtles at times.

In the end, the Shredder is taken prisoner and exiled, while Karai and the young head of the Foot's scientific division, Dr. Chaplin (who has a crush on her) are also captured and taken back to Earth.

This new Shredder "would retain the traditional iconic elements, but have a different treatment"[61] Furious at what she saw as a betrayal by the Turtles, Karai spends the season plotting her revenge against them, first attacking them on the psychic plane via Foot Mystics, and later coordinating and leading an assault against them at their lair.

[72][73] Karai is not involved in any main story lines in the Fast Forward season in which the Turtles and Splinter travel an entire century into the far-distant future, which indicates that she had grown old and died over the decades.

[Note 4] An alternate future version of Karai appears as a villain in an alternate-future third-season episode "Same As It Never Was", in which she is serving the Shredder following his successful conquest of the Earth, in a timeline where Donatello vanished and the Turtles fell apart without his stabilising influence.

Curious about these extraterrestrials and their involvement with the Turtles, Karai had followed to retrieve an inactive Kraangdroid which she demonstrated to the Shredder and Baxter Stockman, thinking that the scientist could make use of such complex technology from space.

Karai made two nonspeaking cameos in "The Legend of the Kuro Kabuto" when she was visited by Shredder who tried to explain that it would have been wrong for her to be raised by "scum like Splinter" and that he had done only what he had to do, what he knew was right.

During the fight, Shredder accidentally causes Karai to fall into the mutagen, turning her into a mutant snake that goes on a rampage before escaping as she regains control of herself when about to kill Splinter.

Although Donatello hopes to create a retro-mutagen to cure Karai, it is revealed that she is a special kind of mutant and can almost completely change back to her human self, retaining only her greenish snake eyes, venomous fangs, and prehensile tongue.

In the second season two-part finale, "The Invasion", Karai had two non-speaking cameos; where she appeared near an alley way to hide from the Kraang, and at the end when she had rescued her biological father from drowning to the death in the sewer.

In the third season episode "Serpent Hunt", Karai is chased by Anton Zeck and Ivan Steranko, Rahzar, and Fishface to be taken to Shredder, who intends to have "his daughter" back, only under his complete control.

Many months later, Karai is later used by Splinter and April as a motivation for the Shredder to aid in fending off the Triceraton invasion in season three two-part finale "Annihilation: Earth!

Finally free of the vile brain-worm that had controlled her, a furious Karai focuses all her efforts on taking down Oroku Saki and his criminal empire with the help of her old friend Shinigami, a Buddhist witch who possesses extraordinarily powerful dark magic.

Before she can rush to her father's aid, more Chrome Domes attack and she watches in horror as Splinter and Oroku Saki fall 1,000 feet; presumably to their deaths.

After escaping (thanks to Shinigami's dark arts) she came to the Lair to warn the Turtles of Tatsu's desire to rule as the new Shredder, with the mutated, legendary Kuro Kabuto itself in his possession.

She resolved for them all to find Tatsu and take him down while recovering the Kuro Kabuto, as it is the key that gives its wearer full control over the entire Foot clan.

In the two-part episode "When Worlds Collide", Karai seems to remain with the Ninja Turtles and her good friend April O'Neil in the Lair, where she frequently spars with Leonardo, whom she expressed her mutual romantic feelings for during their "playful" training sessions.

Upon the destruction of the Newtralizer via electrocution, she expressed sadness when Michelangelo offered to use his temporarily acquired electric-generating abilities to buy her and the Turtles enough time to abandon ship; seemingly sacrificing his own life in the process.

In "The Frankenstein Experiment" Karai, briefly appeared in an illusion that the mummified Pharaoh had cast to torment Leonardo, as a vampire with the Super Shredder behind her, which gravely worried the Turtle leader.

In "The Foot Walks Again" and "The Big Blowout" Karai returned, along with her good friend Shinigami (who was previously injured by Tatsu along with Casey in "Heart of Evil"), and confronts the much less intimidating Shredder from the 2D world of the '80s–90s Ninja Turtles.

She joins up with her allies April and Casey, and later the Ninja Turtles, their 1980s counterparts and the Mighty Mutanimals, to stop the present Bebop and Rocksteady from working with Krang and Shredder to rip apart both dimensions and destroy the entire multiverse.

Karai debuts in the four-part series finale as ancestress of Splinter as the ninja master-turned-rat's maternal great-great-great-great grandmother, which prompted the Turtles to call her "Gram-Gram."

In this comedic series, she is the biological daughter of Oroku Saki as opposed to being adopted by him, who recognized just how corrupt her father's soul was by the dark magical armor that warped him into the relentless, villainous Shredder.