Karaikudi Sambasiva Iyer (1888 - 1958) was a renowned Indian classical musician and Veena player.
He learnt to play Veena from his father, alongside his elder brother, Subbarama Iyer.
His mastery over the instrument was perfect and he constantly toiled to preserve the purity of knowledge he obtained from his ancestors.
In 1957, he adopted Karaikudi S. Subramanian, who was the son of Subbarama Iyer's 3rd daughter Lakshmi Ammal.
Amongst his noted disciples are Kalaimamani and President's award winner (late) Ranganayaki Rajagopalan, Rajeshwari Padmanabhan, Jayalakshmi Sugumar and Karaikudi Subramhanian.