In the Late Qing dynasty, the area that would become Karakax County was divided into four ming (明) (Mandarin Chinese Hanyu Pinyin-derived names): Hayashi (哈雅什明), Buhua (布華明), Makuiya (馬奎牙明), and Kuiya (奎牙明).

On the eve of the creation of the county, the area was divided into six ming (明): Zhawa (扎瓦明), Ying'ai (英愛明) (also known as Tahe (塔合明)), Balamusu (巴拉木蘇明), Kuiya (奎牙明), Makuiya (馬奎牙明), and Ka'ersai (喀爾賽明).

[1][11] On the morning of June 20, 2014, five police officers at a security checkpoint in Kayash village in Manglay township were found dead killed by unknown assailants.

[12] At 3 AM on July 19, 2014, the day after a raid at a local mosque, Zeynep Memtimin, wife of party secretary Rejep Islam, was killed by unknown assailants in an attack at their home.

[17] In February 2020 dissidents leaked the hacked records of 311 detained Uyghurs from a single neighborhood in Karakax County.

The county produces cotton, corn, wheat, melons, silkworm cocoons, black jade and walnuts.

[27] Karakax county has daily bus and taxi to Hotan and other counties like Guma, and also has direct luxury buses to Ürümchi, which is the capital city of Xinjiang, Karakax is also served by China National Highway 315 and the Kashgar-Hotan Railway.