Karen Ann Holbrook (born November 6, 1942, in Des Moines, Iowa) is the regional chancellor of the University of South Florida Sarasota–Manatee since January 2, 2018.

During Holbrook's tenure, she worked with Columbus Mayor Michael B. Coleman to improve safety both on- and off-campus.

[2][3] Holbrook announced in June 2006 that she would depart Ohio State when her five-year contract was up in 2007 to spend more time with her husband, Jim.

[5][6] While applying for a position of President at Florida Gulf Coast University in 2007, Holbrook lamented on the student culture at Ohio State.

She remarked in a job interview that, "They think it's fun to flip cars, to really have absolute drunken orgies.