Karen Lende O'Connor (born February 17, 1958) is an American equestrian who competes in three-day eventing.

At the 2006 World Equestrian Games she rode Upstage as an individual, but did not compete in the team portion of the event.

At the 2000 Summer Olympics, riding Prince Panache, O'Connor and the US team again took a medal, this time bronze.

[11] O'Connor was not originally scheduled to ride in the 2008 Games, but was moved to a competition spot in July 2008 when teammate Heidi White was forced to withdraw.

[12] Four years later, at the 2012 Summer Games, the US team repeated their placing, while O'Connor improved to 9th, riding Mr.

[13] At the 2003 Pan American Games, O'Connor took an individual silver medal, riding Joker's Wild.

In 2008, short-listed for the US eventing team at the 2008 Olympic Games, Teddy suffered a catastrophic injury and was euthanized.

She was out of competition for five weeks, during which time her main mount, Mandiba, was ridden by fellow US eventer Phillip Dutton.

[15] Between 2010 and 2012, O'Connor continued her successful career, riding to multiple top-ten finishes, and several wins, at CCI2–4* events, aboard a number of horses.

[9] On October 6, 2012, O'Connor fell while competing at the Morven Park Fall Horse Trials in Leesburg, Virginia.

[16] In June 2013, it was announced that during the remainder of her recovery, Phillip Dutton would again take over as the rider of her top horse, this time 2012 Olympic mount Mr.