Karen Sisco is an American crime drama television series starring Carla Gugino in the title role.

The series was created by novelist Elmore Leonard, based on a character who had appeared in several of his written works, as well as one film adaptation, 1998's Out of Sight.

Scott Frank, nominated for an Oscar for Best Adapted Screenplay for Out of Sight, served as an executive consultant.

Gugino appeared as "Karen Goodall" in the second episode of the third season of Justified, which is also based on a work by Leonard.

[9] There, the character had been promoted to Assistant Director in the Marshals Service, and had married and divorced, taking and keeping the last name Goodall.