The ideal time to visit Karijini National Park is between May and September, during Australia's late autumn, winter and early spring.

Summer temperatures which regularly reach in excess of 38 °C (100 °F)[contradictory] make it less practical to visit, with added risk of bushfires.

The park is physically split into a northern and a southern half by a corridor containing the Hamersley and Robe River railway and the Marandoo iron ore mine.

[4] Tourist attractions such as gorges and waterfalls are located in the northern half of the park, accessible via sealed and gravel roads.

During that period, Aboriginal land management practices, such as fire-stick farming, resulted in a diversity of vegetation types and stages of succession that helped determine the nature of the plants and animals found in the park today.