Born in Guinea, Cissé began playing football with the Guinean youth clubs AS Aborra and Falcao Academy.

Originally assigned to their reserves, he signed his first professional contract with the club on 1 July 2023 until 2026.

[2] He made his professional debut with Saint-Étienne as a substitute in a 1–0 Ligue 2 loss to Grenoble on 5 August 2023.

[3] In September 2020, Karim Cissé was first called with the Guinea national team by the coach Kaba Diawara.

He comes into play and contributes to his team's victory by delivering a decisive pass for Morgan Guilavogui on the goal of the game alone.