Born in Somero, Finland, Mattila graduated 1983 from the Sibelius Academy in Helsinki, where she studied singing with Liisa Linko-Malmio.
In 1985, she made her Royal Opera House, Covent Garden debut as Fiordiligi in Mozart's Così fan tutte.
Mattila has won Grammy Awards for "Best Opera Recording" for Die Meistersinger von Nürnberg in 1998 and for Jenůfa in 2004.
In 2005, she was named Musician of the Year 2005 by Musical America, which describes her "the most electrifying singing actress of our day, the kind of performer who renews an aging art form and drives the public into frenzies."
However, when Valery Gergiev, who had publicly supported Vladimir Putin's stance on Ukraine and gay rights, was brought in to conduct, she refused to perform if he remained.
[9][5][10][11] Upon the abrupt cancellation of her Jenůfa at the Royal Opera House in late February 2020 because of the COVID-19 pandemic, she moved to an apartment in Helsinki, Finland, until she was able to travel and work safely again and return home.