As chief of staff to Fakhri Pasha, deputy commander of the Ottoman Fourth Army, he was actively involved in the Armenian genocide.

[11] His older sister Freda (1905–1936) was married to the Nazi Henning von Nordeck (1895–1978), who served as a SS-Standartenführer in the staff of the Reichsleitung SS, as early as 1934.

[12] Michel von Tüßling joined the SS (Motorized Unit 2) in Munich in April 1933, shortly after the Nazi Party (NSDAP) seized national power.

In summer 1933 he was transferred to the 1st SS-Standarte in Munich, that was commanded by Viktor Brack, who was also chief of staff to the Reich Secretary of the NSDAP, Reichsleiter Philipp Bouhler.

Bouhler's office was responsible for all correspondences for Hitler which included private and internal communications, appeals from party courts, official judgments, and clemency petitions.

Michel von Tüßling continued his service in Hitler's Chancellery and the SS, and remained the personal adjutant of Bouhler throughout the Aktion T4, the programme of involuntary euthanasia, that ran officially from September 1939 to August 1941, killing more than 70,000 people.

Many KdF employees who participated in T4 later joined Operation Reinhard, the Nazi plan under Odilo Globocnik to exterminate Polish Jews in the General Government district of German-occupied Poland, that was executed from October 1941 till November 1943.

He was on good terms with several Jews of mixed descent and in his official capacity repeatedly acted on behalf of Jews who applied to him for assistance.During the Nuremberg "Doctors' trial", Brack was accused of war crimes and crimes against humanity: Nazi human experimentation, mass murder under the guise of euthanasia, his relation to Aktion 14f13, and his involvement to the implementation of the Final Solution.

Along with Brack and Bouhler, one of his close Nazi Party friends was the former Minister of Armaments and War Production Albert Speer, who regularly visited him on his estate following his release from Spandau Prison in 1966.

[26][27] In her first marriage she was married to Benedict Count Batthyány (born 1960), whose aunt Margit Batthyàny aka "The Killer Countess"[note 1] (1911–1989), a daughter of Heinrich Thyssen, maintained a reconvalescence home for members of the SS (Rechnitz massacre).

[29] From 1999–2005 she was married to Christian Graf Bruges-von Pfuel (* 1942), grandson of General der Panzertruppe Leo Geyr von Schweppenburg.

The second husband of his cousin Marie (1893-1978), Karl Freiherr von Thüngen (1893-1944) was a general in the Wehrmacht who was executed in 1944 after the failed 20 July Plot.