Karl Vilhelm Zetterstéen (18 August 1866 – June 1, 1953) was a Swedish professor and orientalist.
He began his studies at Uppsala University in 1884, became a Ph.D. and docent of Semitic languages in 1895.
He also studied under professor Eduard Sachau (1845–1930) at the University of Berlin.
As a semitist, Zetterstéen was foremost an Arabic philologist, but he was also well-oriented in non-Semitic languages such as Persian, Turkish and Nubian.
Beside a large number of text editions and studies, he published a Swedish translation of the Qur'an and wrote several articles in the Nordisk familjebok as well as a number of popular works.