Karl William Hofmann (born April 6, 1961) is the president and CEO of the global humanitarian and health organization, Population Services International (PSI).

His career has additionally taken him to posts located in Kingston, Jamaica; Kigali, Rwanda; Rabat, Morocco; and Maseru, Lesotho.

[2][3][4] On September 15, 2000, Hofmann was appointed as a Foreign Service Officer to serve as the United States Ambassador to the Republic of Togo.

[7] In February 2007, Hofmann became CEO and President of Population Services International (PSI),[3] a global non-governmental, nonprofit organization, designed to enable low-income and vulnerable people to lead healthier lives.

[8] Since Hofmann became the CEO of PSI, the organization was honored with the largest single grant ever offered for reproductive health work, while additionally receiving nearly $1 billion from The Global Fund to Fight AIDS, Tuberculosis and Malaria.