Karl Friedrich Ernst von Großheim (15 October 1841, Lübeck - 5 February 1911, Bad Rippoldsau) was a German architect and President of the Prussian Academy of Arts.
He began his education at the Großheimsche Realschule, founded by his grandfather, Carl Friedrich Christian von Großheim [de].
At the academy, he made the acquaintance of his future partner, Heinrich Joseph Kayser [de], while both were attending a life drawing course taught by Carl Steffeck.
As their business grew, they opened branches in Bonn and Düsseldorf; the latter managed by Max Wöhler [de], who would become a full partner in 1899.
[citation needed] In his honor, the city of Lübeck created the Von-Großheim-Platz [de] in der Vorstadt St. Jürgen, near his parents' home, in a field that had been left fallow for many years.