Karl Hugo Freiherr von Weizsäcker (25 February 1853 – 2 February 1926) was a German politician who served as Prime Minister of the Kingdom of Württemberg, and a member of the prominent Weizsäcker family.

While serving as a politician at the court of the Kingdom of Württemberg, his family was raised to nobility as von Weizsäcker.

While serving in the administration of King William II of Württemberg, he was raised to the nobility on 24 February 1897.

He served in this office until 6 November 1918, shortly before the monarchy was abolished in the German Revolution of 1918–1919.

[2] In 1916, he and his family were raised to the hereditary noble title of Baron (Freiherr).