She has developed part of her career in North America, featuring in the comedy film The Noble Family (2013) and the narcoseries El Señor de los Cielos (beginning 2013).

Gascón has gained wide attention for portraying the title character in the musical crime film Emilia Pérez (2024), written and directed by Jacques Audiard.

[10][8] Convinced by Mexican filmmaker Julián Pastor, Gascón moved to Mexico in 2009 to continue her acting career, taking on a number of telenovela roles,[11][12] starting with the gypsy Branko in Corazón salvaje.

[13][15][16] In 2014, she appeared in El Señor de los Cielos as the "ruthless" Spaniard Iñaki Izarrieta, an associate of Aurelio Casillas.

[19] Gascón won the festival's Best Actress prize, shared jointly with her three female costars Selena Gomez, Adriana Paz and Zoe Saldaña.

[21] In December 2024, she was reported to have signed on to star as Aunt Encarna in Las malas, an adaptation of Camila Sosa Villada's Bad Girls, set to be directed by Armando Bó.

They were identified as containing bigoted speech against a wide range of communities,[23][24][25][26] including one calling Islam a "hotbed of infection for humanity",[25] and one wondering if the Oscars had become an "Afro-Korean festival", a "Black Lives Matter demonstration", or International Women's Day.