The Karlovy Vary Half Marathon is an annual half marathon race which takes place in mid May in Karlovy Vary, Czech Republic.

Known as the Mattoni Karlovy Vary Half Marathon, it is a part of RunCzech running circuit.

The course winds through Karlovy Vary city centre and along the Ohře river.

The inaugural edition of the event was held in 2013.

The course records are held by Wilfred Kimitei and Yvonne Jelagat.