Written by Keys, Kerry Brothers, Jr., and Taneisha Smith, the song takes influence from hip hop and classical music.

It was released as the album's fourth and final single on November 1, 2004, by J Records.

A mashup of "Karma" with Stevie Wonder's 1972 hit "Superstition" titled "Karmastition", produced by Go Home Productions, was also released.

[1] In the song, the narrator's lover who had left her returns and wants to start a new relationship, but she has moved on.

The music video for "Karma", directed by Chris Robinson and Keys herself, was filmed over three days in August 2004, with parts shot in New York City and at Casa de Campo resort's Altos de Chavón amphitheatre, in La Romana, Dominican Republic.