Although it is followed by the brief "Colors", the album's main piece is the 32-minute-long "The Creator Has a Master Plan", co-composed by Sanders with vocalist Leon Thomas.

It features Sanders on tenor sax, along with two of his most important collaborators, the aforementioned Leon Thomas and pianist Lonnie Liston Smith, as well as a supporting cast of musicians who were major musicians in their own right: flautist James Spaulding; French-horn player Julius Watkins; bassist Reggie Workman, who had played with Coltrane earlier in the 1960s; second bassist Richard Davis; drummer Billy Hart, and percussionist Nathaniel Bettis.

The unusual textures also give an impression of the exotic, with the employment of a French horn and flute, adding an almost orchestral tinge not often found in jazz, as well as Leon Thomas' characteristic yodelling and a variety of percussion instruments.

The influence of the "spiritual jazz" movement, and Sanders' involvement in particular, can be seen in Sarah Webster Fabio's 1976 lyrics to "Jujus: Alchemy of the Blues": You prophesied the return of mandolins and tambourines and tinkling bells, and triangles and cymbals, and they sided in on beams from Pharoah Sanders as I slept taking me unaware, tripping, blowing my mind.

—Sarah Webster Fabio, 1976 For the 1995 compact disc reissue, "The Creator Has a Master Plan" was re-edited back to a single track with a running time of 32:46.