She began her career as a child, in the Latin American telenovela La Rosa De Guadalupe and she played Luna Valente in the Disney Channel series Soy Luna (2016–18).

Karol Sevilla was born in Mexico City, and has an older brother named Mauricio.

Karol Sevilla began her artistic career in television commercials at the age of six.

Since then, she has appeared in numerous television series including: Amorcito corazón, Como dice el dicho, and La rosa de Guadalupe.

In 2021, she was set to star in the Disney+ original drama series Siempre Fui Yo as Guadalupe Díaz.