Karpathos-Kasos (Greek: Περιφερειακή Ενότητα Καρπάθου - Ηρωϊκής Νήσου Κάσου, literally: "Regional Unit of Karpathos - Heroic Island of Kasos") is one of the regional units of Greece.

The regional unit covers the islands of Karpathos, Kasos, Saria and several smaller islands in the Aegean Sea.

As a part of the 2011 Kallikratis government reform, the regional unit Karpathos was created out of part of the former Dodecanese Prefecture.

These are (number as in the map in the infobox):[3] The province of Karpathos (Greek: Επαρχία Καρπάθου) was one of the provinces of the Dodecanese Prefecture.

This South Aegean location article is a stub.