[2] Kasane briefly obtained international fame as the location of the remarriage of Elizabeth Taylor to Richard Burton, in 1975.

The town lies on the south bank of the 200–300 metres (660–980 ft) wide Chobe River which forms the border with the extreme tip of Namibia's Caprivi Strip.

The Namibian island of Impalila lies opposite the town on the north bank of the river, and there is a border crossing by passenger ferry to Namibia.

Nearby a second border post serves the road into Zimbabwe which runs 70 kilometres (43 mi) east to Victoria Falls.

Kasane is at the northern end of the tarred highway from Francistown and Gaborone which is a regional artery between southern and central Africa particularly for trucks too heavy for the Victoria Falls Bridge's periodic weight restrictions.