The Volga, built as the Uglich Reservoir, makes the southeastern border of the district.

It is unclear when Kashin was founded, with plausible dates in the 12th and the 13th centuries, and it is reliably mentioned in 1287, when it belonged to Principality of Tver.

In 1775, Tver Viceroyalty was formed from the lands which previously belonged to Moscow and Novgorod Governorates, and Kashinsky Uyezd was established.

Kashinsky District, with the administrative center in Kashin, was established within Bezhetsk Okrug of Moscow Oblast.

Buses connect the district with Tver and Moscow, as well as provide local transportation.

The district contains fifty-two cultural heritage monuments of federal significance (thirty-six of them located in Kashin) and additionally eighty-seven objects classified as cultural and historical heritage of local significance (fifty-six of them in Kashin).

The federal monuments are the historical buildings in the center of Kashin, including the ensemble of the Presentation Monastery, a number of churches built in the 18th and the 19th centuries, the Shepeli Estate in the selo of Shepeli, as well as a number of archeological sites.