She began her acting career at the age of eight as Katie Murray, playing an episodic role in the television series MacGyver in 1989.

Then she continued to act in small episodic roles in television series and films such as: Cold Front, Immediate Family, The Last Winter, Burning Bridges,[8] Children of the Dust, Salt Water Moose,[9] and Married to a Stranger.

[11][12] What Culture said: Obsessed with death and morbidity, and afraid of adulthood, Ginger Fitzgerald, portrayed by Katharine Isabelle of American Mary fame, only gets worse when she's bitten by a lycanthrope and the transformation into a wolf begins.

She gradually becomes aggressive and over-sexualised, loses her relationship with her sister, grows pointy teeth and sprouts hair in really weird places.

[13]Jessica Roakes of The Toast also mentions the metaphorical nature of the character saying "Ginger’s body has betrayed her by menstruating.

This is a key tenet of the body-horror genre — the monstrous comes not just from the outside, but from within the human body, from infection or perversion or unwanted biological functions.

[16] In this detective thriller directed by Christopher Nolan, the actress played along with Al Pacino, Robin Williams and Hilary Swank.

Cooperation with the gothic sisters continued in 2014 when Isabelle played a major role in their 2006 horror sequel, See No Evil 2.

[19] Despite acting in a large number of gory films and television productions, Isabelle is uneasy with the sight of real blood.