She previously worked at the National Museum of the American Indian's George Gustav Heye Center for two decades.

In 2024 Ash-Milby curated the exhibition for the American pavilion at the 60th Venice Biennale featuring artist Jeffrey Gibson.

[1] Ash-Milby began her career as a curatorial research assistant at the George Gustav Heye Center in New York City, a branch location of the Smithsonian's National Museum of the American Indian (NMAI).

[3] In 2001 Ash-Milby began working at the American Indian Community House (AICH) Gallery, a New York nonprofit that provides services for Native people living in the city.

[2] In conjunction with the 60th Venice Biennale in 2024, Ash-Milby commissioned and co-curated artist Jeffrey Gibson's solo exhibition The Space in Which to Place Me for the American pavilion.