She gained prominence through her roles in the BBC sitcom Two Pints of Lager and a Packet of Crisps (2001–2009) and the films Vanity Fair (2004) and St Trinian's (2007).
[5] From 2001 to 2009, Drysdale starred as Louise Brooks in the BBC sitcom Two Pints of Lager and a Packet of Crisps for eight out of nine series of the show.
She made her film debut in Mira Nair's 2004 feature adaptation of William Thackeray's Vanity Fair as heiress Rhoda Swartz.
In 2006, she played Lizzie in the British-Australian Channel 5 and Network Ten drama Tripping Over and Bliss in the Doctor Who series 2 episode "Love & Monsters".
She voices the lead character of Bounce in the CBBC animation series Bottersnikes and Gumbles and plays the role of Genevieve Delacroix in Netflix show Bridgerton.