[2] Newton has appeared in various films, including Bad Teacher (2011), Three Billboards Outside Ebbing, Missouri (2017), Blockers (2018), Pokémon Detective Pikachu (2019), Freaky (2020), The Map of Tiny Perfect Things (2021), Ant-Man and the Wasp: Quantumania (2023), and Abigail (2024).

[13][7] Newton started her career at age four, making her television debut on the soap opera All My Children,[14] playing Colby Marian Chandler from 2001 to 2004.

[14] In 2008, Newton was cast in the role of Louise Brooks in the CBS television series Gary Unmarried.

When she was twelve, her family moved to Los Angeles,[15] where she attended the Notre Dame High School.

In 2020, she starred in the well-reviewed horror comedy film Freaky, directed by Christopher Landon, as a teenage girl who switches bodies with a serial killer.

[24] She portrays Cassie Lang[25] in the Marvel Cinematic Universe film Ant-Man and the Wasp: Quantumania replacing Emma Fuhrmann in the role.