Cox sought re-election in 2006, defeating Democratic challenger Denise Majette (a former U.S. representative), earning almost 60 percent of the vote.

[3] In May 2010, she announced her resignation effective July 1, 2010 in order to take a position as CEO of a new non-profit U.S. Education Delivery Institute in Washington D.C.[4] She did not seek a third term in office.

Georgia Governor Sonny Perdue appointed Brad Bryant as the interim State School Superintendent until a replacement (John Barge, a Republican) was elected in November 2010.

In justifying her decision, she claimed evolution was a buzzword that created problems for teachers in conservative and rural areas, and that she had not been attempting to water down the subject matter.

[3] On August 19, 2009, protesters representing deaf and blind children picketed the office of bankruptcy attorney Gary W. Brown in Newnan, over his efforts to take control of the winnings.