[1] In 2017 Fantagraphics Books published Skelly's first hardcover graphic novel My Pretty Vampire, notable for its "dramatic colors" and "sense of mercurial motion".

[2] Inspired by the Italian horror films of Dario Argento and the early work of comics illustrator Jean-Claude Forest,[3] the story follows a young vampire who escapes captivity by her brother to discover herself through surreal, sensual and often violent adventures in the modern world.

Skelly's other works include Operation Margarine (2014, Adhouse Books), for which she was awarded the inaugural Emerging Artist Prize at the Cartoon Crossroads Columbus Festival in 2015;[4] The Agency (2018, Fantagraphics Underground); and illustrations for the Alex de Campi penned Twisted Romance: Heartbreak Incorporated (2018, Image Comics), which received a 2019 Eisner Awards nomination for best anthology.

[8] Library Journal's advance review of the book discusses the "horror of the Papin sisters’ crimes," noting that Skelly's "perceptive examination of the complex bond between Catherine and Lea evokes incredible sympathy for the two nonetheless.

"[9] Skelly's first solo exhibition Skellyworld ran at The Naughton Gallery at Queen's University Belfast in Northern Ireland August 8 through October 6, 2019.