She was previously the distinguished investigator and director of translational and applied genomics at the Kaiser Permanente Center for Health Research and a faculty member at Case Western Reserve University.

[4][3] In 2007, Goddard joined the Kaiser Permanente Center for Health Research [Wikidata] in Portland, Oregon as a distinguished investigator and director of translational and applied genomics.

While at Kaiser Permanente, Goddard was the founding director for the NW Biobank, and she was a principal investigator (PI) of the Cancer Health Assessments Reaching Many (CHARM) study as part of the National Human Genome Research Institute (NHGRI)-funded Clinical Sequencing Evidence-Generating Research (CSER) consortium, which has an overarching goal of investigating the integration of genome-scale sequencing into clinical care for diverse and medically underserved individuals.

Goddard was the site PI of the Kaiser Permanente Northwest partner site for the NCI-DCEG Connect for Cancer Prevention Study (Connect), a new prospective cohort seeking to enroll 200,000 adults in the United States from nine integrated health care systems and designed to further investigate the etiology of cancer and its outcomes.

In this position, she oversees a division that covers a wide range of scientific domains and disciplines, including epidemiology, behavioral science, surveillance and statistics, cancer survivorship, and health services and outcomes research.