[2] She has written widely on testosterone, intersex issues, sex verification in sports, treatment practices, policy and lived experiences, and the interface between medicine and society.

[3][7] After spending 15 years at Stanford, she was the Carol Zicklin Endowed Chair in the Honors Academy at Brooklyn College, City University of New York.

Gary Berkovitz, writing in the New England Journal of Medicine states that Karkazis's analysis is fair, compelling, and eloquent.

"[15] Mijeon, in American Journal of Human Genetics writes that the "conclusion is quite fitting", "the history of thinking about the body ... can be highly politicized and controversial".

[16] Kenneth Copeland MD, former president of the Lawson Wilkins Pediatric Endocrine Society describes the book as, "Masterfully balancing all aspects of one of the most polarizing, contentious topics in medicine... the most recent authoritative treatise on intersex.

[24] In Emotionally and cognitively informed consent for clinical care for differences of sex development, co-authored with Anne Tamar-Mattis, Arlene Baratz, and Katherine Baratz Dalke and published in 2013, the authors write that "physicians continue to recommend certain irreversible treatments for children with differences of sex development (DSD) without adequate psychosocial support".

The Controversy over “Disorders of Sex Development”, co-authored with Ellen Feder and published in 2008, the authors state that "tracing "the history of the terminology applied to those with atypical sex anatomy reveals how these conditions have been narrowly cast as problems of gender to the neglect of broader health concerns and of the well-being of affected individuals.