She made her debut in July 2003 with the publication of her first manga series Continue and is known for her work, D.Gray-man, which began serialization in Shueisha's Weekly Shōnen Jump in May 2004.

Hoshino has been highly praised for her art, which has been compared to the works of Joe Madureira, Kelley Jones, and Chris Bachalo by one reviewer and described as "some of the best artwork in the business" by another.

Hoshino was born on April 21, 1980, in Shiga Prefecture, Japan, as the younger of fraternal twin girls and the second of three children.

[4] As a child she used to read the manga Dragon Quest: Dai no Daibōken that her brother collected, as well as series by Fuyumi Soryo and Makimura Satoru, which her mother bought.

When going to highschool, Hoshino started drawing which she believed to be the result of reading Naoko Takeuchi's manga Sailor Moon.

She still felt troubles in her new job, due to the multiple hours at work, the problems with storyboards and having to take the bullet train.

[7] After graduating from high school, Hoshino did not know what career should she follow as she was offered the work of joining video game companies.

[9][10] Due to lack of popularity of Continue, the Shueisha staff recommended Hoshino to make a series based on Zone.

[11] The series is over two hundred chapters long in Japan and is sold in over ten countries, including the United States, France, and Germany.

[35][36][37][38] In November 2008, Weekly Shōnen Jump announced that Hoshino was again putting the series on hold due to an injured wrist.

Leroy Douresseaux of Coolstreak Cartoons called Hoshino a "wonderful visualist" and commented that her "highly stylish" art resembled the works of Joe Madureira, Kelley Jones, and Chris Bachalo.

[48][49] Douresseaux describes the backgrounds as eerie and Lovecraftian and says that Hoshino "makes practically every page a delightful surprise of gothic style and beguiling violence".

[49][50] The reviewer Charles Tan from ComicsVillage.com feels the art deserves less praise, saying that it is done competently enough to distinguish characters while still providing flashy scenes with the common themes of a shōnen series.

Leary believes that Hoshino simply cannot or will not draw physical combat and instead chooses to rely on energy blasts, swirling wind, and impact bursts.

[8] By the release of the series' 13th collected volume, Hoshino revealed the material she uses when working, which included a PlayStation Portable, an iPod and a glove her mother made for her.

[67] Towards the beginning of D.Gray-man's publication, Hoshino stated that Allen, Kanda, and Cross Marian are the hardest characters to draw while the Millennium Earl and Hevlaska are the easiest.

[69] As she works, she enjoys listening to Final Fantasy soundtracks, Dragon Ball CDs, the bands Porno Graffitti, L'Arc-en-Ciel, and jazz music.

[72][73] The story arc involving Alma Karma proved Hoshino to difficult due to the fact it featured several characters.

[71] In order to gather research for the series, Hoshino once visited New York as she believes the city left a deep influence in her works.

The ground zero of the World Trade Center after the September 11 attacks also left a big impression in her based on the guides' comments.