Katy B performed at the London Jazz Festival in 2009 with Ms Dynamite, who also featured on Katy's second single, "Lights On" which was released in the United Kingdom on 19 December 2010, and debuted at number four on the UK Singles Chart.

Her third single "Broken Record" was released in March 2011, and peaked at number eight.

In 2011, Katy B and Mark Ronson teamed up for the song "Anywhere in the World" created as an advert for the Coca-Cola and the 2012 Summer Olympics, which was released as a digital download on 13 May 2012.

"Crying for No Reason" was released in January 2014 as the second single from her second studio album, which peaked at number 5.

Alongside KDA and Tinie Tempah, Katy B reached number 1 in 2015 with "Turn the Music Louder (Rumble)".