The second significant redesign in 2022 added new features such as electronic fuel injection and an anti-lock braking system.

The addition of luggage and personalized modifications (GPS, heated handgrips, larger windscreens) make it more functional on long trips.

The bikes have been used for long distance and intercontinental trips, as well as full global circumnavigation rides e.g., by Dr. Gregory Frazier in 2001 and 2002.

With the numerous changes and improvements, the second generation KLR gained 16 lb (7.3 kg) of dry weight to the bike.

Variants KLR650-S: Introduced in 2023, this variation offers shorter foot pegs, higher hand grips, and a slightly slimmer seat.