In 1999, Hanley appeared as herself in the film 10 Things I Hate About You, singing a cover version of Nick Lowe's "Cruel to Be Kind" to Heath Ledger and Julia Stiles at their characters' high school prom, in addition to performing original song "Come On" with Letters to Cleo during an earlier scene at a club.

In September 2005, she appeared on The Tonight Show with Jay Leno as part of a pre-taped man-on-the-street segment, singing a song about falling in love at Starbucks.

Hanley is popular with fans of the New England Patriots thanks to the team at one point going 8–0 after she sang the pre-game National Anthem at Gillette Stadium.

Hanley is also very involved with the Boston-based charity "Hot Stove, Cool Music," both as performer and spokesperson for the semi-annual event, which has raised over 6 million dollars for The Foundation To Be Named Later She sang the theme song [3] for My Friends Tigger & Pooh,[4] a half-hour Disney Channel TV show that premiered on Playhouse Disney on May 12, 2007, and "We Are Care Bears" from Care Bears: Oopsy Does It!

Due to her work with SONA in getting the Music Modernization Act passed into law in October 2018, Hanley was elected Vice Chair of the Mechanical Licensing Collective's Unclaimed Royalties Oversight Committee in August 2019 On Thanksgiving Day 2007, Hanley sang a song called "Caring Changes The World" in the Macy's Thanksgiving Day Parade on the Care Bears float.

The character of Ben Wyatt, played by Adam Scott, is seen offstage in his Letters to Cleo t-shirt, blissfully watching the band as Hanley winks at him.

"[6] Later that year, she appeared on Saving for a Custom Van, a tribute album for Adam Schlesinger, with whom she had worked on Josie and the Pussycats, following his death from COVID-19.

Oh 2023, Hanley and her fellow Letters to Cleo bandmate Tom Polce wrote the songs for “Subspace Rhapsody,” an episode of Star Trek: Strange New Worlds performed in the style of a broadway musical.

The title of this section indicates projects that both Hanley and Eisenstein have taken an active interest in developing, in terms of playing multiple roles, including production as well as composition and/or instrumentation.