She then took on leading roles in a variety of films, such as Wuthering Heights (2011), the Maze Runner series (2014–2018), Pirates of the Caribbean: Dead Men Tell No Tales (2017), Crawl (2019), and Resident Evil: Welcome to Raccoon City (2021).

[10] Her mother took on multiple jobs to make ends meet and had clinical depression that worsened during Scodelario's teen years.

[13][non-primary source needed] Critics praised her performance, and she was nominated twice for Best Actress at the TV Quick Awards, in 2009 and 2010.

[14] In the episode "Fire", one of three parts of the seventh (and final) season of Skins, Scodelario reprised the role of Effy.

In April 2010, Scodelario confirmed her casting as Cathy in an adaptation of Wuthering Heights directed by Andrea Arnold.

[27] In September 2011, Scodelario filmed a television serial for BBC One, True Love, an improvised series comprising five stand-alone episodes, each covering a different love-related dilemma.

She stars as the title character, Emanuel, a troubled 17-year-old girl who babysits her new neighbour Linda's "baby", which is actually a very lifelike doll.

[31] In 2013 she starred in the four-part Channel 4 drama series Southcliffe, which tells the story of a fictional English town devastated by a spate of shootings, exploring the tragedy through the eyes of a journalist and those close to the victims.

The first, released in May, was Extremely Wicked, Shockingly Evil and Vile, about serial killer Ted Bundy; she portrays his wife, Carole Ann Boone.

[41] She played the lead in Alexandre Aja's horror film Crawl, which was released in July to positive reviews.

[43] Scodelario then signed up to lead a new Netflix series, an edgy figure skating drama called Spinning Out in 2019.

[44] Debuting in early 2020, the series explored multi-person mental illness within a family and its interaction with high-level competitive sports.

[46] In August 2021, Scodelario joined dramedy Don't Make Me Go being developed under Amazon Studios, and filmed This Is Christmas the next summer.

[50] Scodelario dated her Skins co-star Jack O'Connell for about a year before they split up in June 2009, remaining good friends.