In addition to co-hosting Outnumbered she serves as a primary guest host for The Ingraham Angle, Jesse Watters Primetime, Hannity, The Five and Fox & Friends.

After graduating, she majored in international politics at Georgetown University's School of Foreign Service in Washington, D.C.,[7] and she studied abroad at St Edmund Hall, Oxford.

[4] As a college student, McEnany interned for several politicians, including Tom Gallagher, Adam Putnam and George W. Bush, and later worked in the White House Office of Communications, where she wrote media briefings.

In an interview with the New York Times, Marcantonio recalled telling McEnany, "Donald Trump is going to be your nominee," and that if "a smart, young, blond Harvard graduate" wanted "to get on television and have a career as a political pundit, you would be wise to be an early backer.

[4] In 2017, she said it was hypocritical to accuse President Trump of spending time playing golf when Obama had done the same thing after the 2002 beheading of Daniel Pearl.

McEnany later apologized for the comment, acknowledging that Obama was a senator at the time although he did go golfing after the 2014 beheading of another journalist, James Foley, by ISIS in Syria.

Obama, who was vacationing on Martha's Vineyard at the time, admitted that he should have "anticipated the optics" of golfing immediately after making a press statement on Foley's death.

[22][23] In 2017, as RNC spokeswoman, McEnany supported Trump amid a bipartisan backlash in response to his comments about a white supremacist rally in Charlottesville, Virginia, in which he suggested that white supremacists and anti-racist counterprotesters shared blame for violence; in a tweet, McEnany wrote that the Republican Party supported Trump's "message of love and inclusiveness.

"[24] In August 2019, after The Washington Post reported that Trump had made 16,241 false or misleading statements in his first three years in office, McEnany told CNN's Chris Cuomo: "I don't believe the president has lied.

"[25] In the weeks before her appointment as White House press secretary, McEnany praised Trump's handling of the COVID-19 pandemic, saying, "This president will always put America first, he will always protect American citizens.

[29] Stephanie Grisham, who had served in the role and as White House communications director since June 2019, became First Lady Melania Trump's chief of staff and spokesperson.

[30] Two months into her tenure, the Associated Press wrote of McEnany, she "has made clear from her first briefing that she's willing to defend her boss's view of himself as well as his most flagrant misstatements.

"[31] In April 2020, McEnany defended Trump's assertion that the World Health Organization had shown a "clear bias towards China" and said that the WHO put Americans at risk by "repeating inaccurate claims peddled by China during the coronavirus pandemic" and "opposing the United States' life-saving travel restrictions.

McEnany responded the next day by providing a statement to CNN claiming that, to the contrary, the "response has been unprecedented and saved American lives.

[40] In June 2020, she defended the decision by the Trump administration to forcibly remove peaceful protestors using smoke canisters, pepper balls, riot shields, batons, officers on horseback and rubber bullets[41] so that Trump could stage a photo op in front of St. John's Episcopal Church, Lafayette Square in Washington.

She likened Trump's action to that of Winston Churchill walking the streets to survey bomb damage during World War II.

"[43] On September 9, 2020, news agencies released the audio recordings of interviews with Trump that former Washington Post journalist Bob Woodward had conducted in February and March 2020 for his book Rage, in which Trump acknowledged to Woodward that he was intentionally downplaying the severity of the SARS-CoV-2 coronavirus, which CNN had obtained ahead of the book's September 15, 2020 release.

"[45] In fact, Trump repeatedly and publicly downplayed the risk of the virus and the severity of the pandemic, and in a recorded March 19, 2020 interview with Woodward said, "I wanted to always play it down.

[66][67] Due to a BRCA mutation that put her at high risk of developing breast cancer, McEnany underwent a preventive double mastectomy in 2018.