Located within the larger Eastlands area of Nairobi, it is approximately 11 kilometres (6.8 mi) east of the central business district.

Kayole is located approximately 11 kilometres (6.8 mi) east of Nairobi's central business district, straddled by Kangundo Road to the south, within the Eastlands area in Embakasi.

Due to its affordability, Kayole hosts low-income earners, holding a significant percentage of the city's population.

[3] A significant number of residents in Kayole are unemployed, live in abject poverty, and can barely raise $1 a day.

[4] In terms of security, Kayole is riddled with criminal gangs, kidnappings, armed and aggravated robberies, theft, as well as child trafficking.