Lewis attended O. Perry Walker High School in New Orleans, Louisiana and was schoolmates and teammates with NFL wide receiver Mike Wallace.

He started training camp on the physically unable to perform list, and although the team activated him from PUP on August 3, 2016, he practiced just one day and had been sidelined ever since.

On April 25, 2016, it was reported that the Steelers met with Keenan Lewis and explored a possible agreement with the free agent.

He underwent an MRI and a physical and it was discovered Lewis was still dealing with the hip injury that caused his release from the Saints.

[7] On April 29, 2017, the Steelers again hosted Lewis on a visit to look into the possibility signing the free agent, but again decided against it.