Some of the largest academic programs at Keene State College are Education, Business Management/Management, Psychology, Safety & Occupational Health Applied Sciences, and Criminal Justice Studies, according to the declared majors reported in the Keene State College Factbook.

[3] Keene's Factbook 2019-2020 shows that Exercise Science and Criminal Justice Studies are some of the fastest growing majors.

This program began holding an annual professional development conference in conjunction with the student ASSE (American Society of Safety Engineers) chapter.

Keene State College is also the first accredited university in the nation to offer a four-year undergraduate degree in Holocaust and Genocide Studies.

[8] Keene State, known athletically as the Owls, is an NCAA Division III school, competing in the Little East Conference.

[10] Opened in 2010 and houses the College Advancement Division: Alumni & Constituent Relations, Development, and Marketing & Communications.

This building is designed to accommodate reunion banquets, class meetings, job fairs, and other campus and community events.

It is one of the oldest dorms on campus and is rumored to be haunted by the ghost of its namesake, Harriet Lane Huntress, a former administrator in the New Hampshire Department of Education.

The library is named for Wallace Edward (Daddy) Mason, who was the President of Keene Normal School from 1911 until 1939.

In 2018, a new wing of the building was opened which includes an expanded Cohen Center for Holocaust and Genocide Studies.

In Fall 2021, the Center for Research & Writing moved from its original location on 81 Blake Street into a larger dedicated space in the Mason Library, offering peer tutoring services in speaking, researching, and writing processes.

Pondside II houses 120 co-ed residents - all juniors and seniors - in four-person, carpeted apartments.

Each apartment consists of four single bedrooms, a shared bathroom, living area, and a kitchen equipped with a stove, oven, microwave, and refrigerator.

The building also houses fine arts classes including painting, drawing, sculpture and printmaking.

The Spaulding Gymnasium and Recreation Center is open to all KSC students and faculty free of charge, and to the general public for a fee.

Within the Zorn building but outside the dining area proper is the Hoot-N-Scoot/SONO, a take-out facility with prepackaged meals.