At the end of junior high school, he was awarded a national scholarship after he passed the Brevet des collèges in Syria (1980).
In 1983 he was awarded a scholarship to study medicine in the United Kingdom after completing the Syrian Baccalaureate national examination with full marks.
Kefah Mokbel learned English in Eastbourne and then studied A levels in a boarding school (Concord College) in Shrewsbury.
He was granted the Master of Surgery degree in 2000 by The Imperial College of Science, Technology and Medicine for his research in the field of molecular biology of breast cancer.
Mokbel's main research interest lies in the field of molecular biology and the clinical management of breast cancer.
In October 2018, Mokbel and his team reported that the use of testosterone gel for hyposexual desire might not increase breast cancer risk among women using it.