Keio-Horinouchi Station (京王堀之内駅, Keiō-Horinouchi-eki) is a passenger railway station located in the city of Hachiōji, Tokyo, Japan, operated by the private railway operator Keio Corporation.

Keio-Horinouchi Station is served by the Keio Sagamihara Line between Chōfu in Tokyo and Hashimoto in Kanagawa Prefecture.

Semi Express, Rapid, and Local services stop at this station.

The station consists of two elevated opposed side platforms serving two tracks.

The station building and combined shopping center is located underneath and to the side of the tracks.