A Great Britain and Wales international representative hooker, he played his entire professional career at St Helens, making nearly 500 appearances for the club between 1994 and 2010 and winning numerous trophies.

Keiron Cunningham was born five months after his brother Eddie won a Rugby League Challenge Cup winner's medal for St Helens against Widnes.

[10] He made his début in the 1994–95 Rugby Football League season, and soon established himself as a world class hooker, renowned for his dynamic running from dummy half and ability to poach tries from short distances.

Keiron Cunningham played hooker, and scored a try in St. Helens' 16-25 defeat by Wigan in the 1995–96 Regal Trophy Final during the 1995–96 at Alfred McAlpine Stadium, Huddersfield on Saturday 13 January 1996.

[11] Cunningham played for St Helens at hooker in the 1996 Challenge Cup Final, scoring a try in the second half of the match and helping his team to a 40-32 victory over the Bradford Bulls.

St Helens reached the 2006 Super League Grand final to be contested against Hull FC, and Cunningham played at hooker, scoring a try in Saints' 26-4 victory.

Following a supporters' poll featuring the likes of Tom van Vollenhoven and Alex Murphy, Cunningham was chosen to be cast as a bronze statue outside of Langtree Park.